This book is aimed at those who wish to understand more about the molecular basis of life and how life on earth may change in coming centuries. Readers of this book will gain knowledge of how life began on Earth, the natural processes that have led to the great diversity of biological organisms that exist today, recent research into the possibility of life on other planets, and how the future of life on earth faces unprecedented pressures from human-made activities. Readers (...) will obtain a perspective on the potential risks of chemical or nuclear warfare, and the ever-increasing risks from human activities that are causing pollution and climate change with global heating. Readers will also learn about ongoing research efforts to generate “designer lifeforms” through synthetic biology and applications of artificial intelligence. The book makes an integrated, up-to-date, overview of topics often considered as separate fields. It should be valuable to students, teachers, and people who are concerned about the future of life. (shrink)

In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneous microenvironment that has important supportive and instructive roles. Although the primary site of action of ECM proteins is extracellular, evidence is emerging for non‐canonical intracellular roles. Examples include osteopontin, thrombospondins, IGF‐binding protein 3 and biglycan, and relate to roles in transcription, cell‐stress responses, autophagy and cancer. These findings pose conceptual problems on how proteins signalled for secretion can be routed to the cytosol or nucleus, or can function in environments with (...) diverse redox, pH and ionic conditions. We review evidence for intracellular locations and functions of ECM proteins, and current knowledge of the mechanisms by which they may enter intracellular compartments. We evaluate the experimental methods that are appropriate to obtain rigorous evidence for intracellular localisation and function. Better insight into this under‐researched topic is needed to decipher the complete spectrum of physiological and pathological roles of ECM proteins. -/- . (shrink)

Despite recent empirical interest, the links between optimism and pessimism with pro-environmental behavior remain equivocal. This research is characterized by a reliance on cross-sectional data, a focus on trait-level at the neglect of state-level optimism–pessimism, and assessments of retrospective self-reported ecological behavior that are subject to response bias. To attend to these gaps, 140 North American adults were experimentally primed with bogus optimistic or pessimistic environmental news articles, and then asked to report their levels of state optimism–pessimism, intentions to purchase (...) green products, in vivo PEB, and support for geoengineering technologies. Results confirmed that optimistic environmental messaging enhanced the expression of state optimism, which then contributed to PEB and support for geoengineering. These results have important implications for the framing of environmental messaging intended to promote ecologically conscious behavior. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

If Savulescu's (2001, 2009) controversial principle of Procreative Beneficence (PB) is correct, then an important implication is that couples should employ genetic tests for non‐disease traits in selecting which child to bring into existence. Both defenders as well as some critics of this normative entailment of PB have typically accepted the comparatively less controversial claim about non‐disease traits: that there are non‐disease traits such that testing and selecting for them would in fact contribute to bringing about the child who is (...) expected to have the best life. We challenge this less controversial claim, not by arguing deductively for its falsity, but by showing that Savulescu's central argument for this presumably less controversial claim fails. Savulescu offers intelligence as the paradigm example of a testable non‐disease trait such that testing and selecting for it would increase the likelihood that the child selected would be the one who is expected to have the best life (or at least as good a life as the others). We provide a series of arguments aimed at demonstrating that Savulescu's argument from intelligence fails. If our arguments are successful, the upshot is not that PB is false, but more modestly, that the burden of proof remains squarely with Savulescu. (shrink)

According to certain kinds of semantic dispositionalism, what an agent means by her words is grounded by her dispositions to complete simple tasks. This sort of position is often thought to avoid the finitude problem raised by Kripke against simpler forms of dispositionalism. The traditional objection is that, since words possess indefinite (or infinite) extensions, and our dispositions to use words are only finite, those dispositions prove inadequate to serve as ground for what we mean by our words. I argue (...) that, even if such positions (emphasizing simple tasks) avoid the traditional form of Kripke's charge, they still succumb to special cases of the finitude problem. Furthermore, I show how such positions can be augmented so as to avoid even these special cases. Doing so requires qualifying the dispositions of interest as those possessed by the abstracted version of an actual agent (in contrast to, say, an idealized version of the agent). In addition to avoiding the finitude problem in its various forms, the position that results provides new materials for appreciating the role that abstracting models can play for a dispositionalist theory of meaning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Closing the Gaps in Pediatric HIV/AIDS Care, One Step at a TimeLisa V. Adams, Helga Naburi, Goodluck Lyatuu, Paul Palumbo, and C. Fordham von ReynFatuma's* doctors were completely perplexed. It was 2003 and she had returned to the DARDAR clinic in her hometown of Dar es Salaam, Tanzania three times that week with vague complaints of various pains and aches. Her doctors were considering whether these symptoms were due (...) to the initiation of her recent treatment with antiretroviral medications for her HIV infection or related to the last administration of the investigational tuberculosis (TB) vaccine that the DARDAR Health Study was evaluating. Fatuma's doctor, Dr. Lillian Mtei, consulted with Dartmouth's chief of Infectious Disease, Dr. Ford von Reyn, who happened to be in Dar that week on a site visit. Neither physician could determine the basis for her symptoms. Dr. Mtei returned to the exam room once more and this time emerged with the answer: Fatuma had just learned that her three year old daughter was HIV-infected, likely contracted from Fatuma during or shortly after she gave birth to her daughter. Fatuma believed that her HIV diagnosis was a death sentence for her daughter since antiretroviral therapy was not widely available for children.Dr. von Reyn, Dartmouth's lead clinical researcher in Africa and a father, knew too well the harsh reality of inequities in a resource-limited country. He turned to Dr. Mtei and said decidedly, "we need to do something about this."Thus the DARDAR Pediatric Program was born.Pediatric HIV: A Neglected DiseaseThe need for HIV treatment among children in Tanzania, as in most of sub-Saharan Africa, is compelling. At the end of 2009, approximately 160,000 children aged zero to fourteen in Tanzania were living with HIV (Joint United Nations Programme on HIV/AIDS [UNAIDS], 2011). Even with successful roll out of prevention of mother to child transmission programs in Tanzania, there were nearly 29,000 perinatal infections in 2009. As of December 2010, only 18% of these were enrolled in HIV treatment programs (UNAIDS, 2011; World Health Organization [WHO], 2011). Without antiretroviral therapy (ART), one-half of HIV-infected children will die before their second birthday. Since clinical research to determine efficacy and safety of new medical treatments is conducted almost exclusively in adults, provision of new medical treatments to [End Page 75] children always lags behind advances for adults. Furthermore, children are often underrepresented in programs for antiretroviral drugs for the following reasons: 1) they are not prioritized for care; 2) facilities lack infant diagnostic capabilities; 3) there is limited pediatric HIV training and consequently, a shortage of pediatric providers; and 4) pediatric antiretroviral formulations are frequently unavailable. The unacceptable delays in pediatric HIV drug development and treatment access led the international organization Drugs for Neglected Diseases initiative to publish an editorial in which they referred to pediatric HIV as a "neglected disease" (Lallemant, Chang, Cohen, & Pecoul, 2011).The Tip of the Iceberg: More than Just MedicinesWith a grant from the New York-based Foundation for the Treatment of Children with AIDS, the DARDAR Pediatric Program, a joint collaboration between Geisel School of Medicine at Dartmouth and Muhimbili University of Health and Allied Sciences, began seeing patients in May 2006. It was the first dedicated pediatric HIV Care and Treatment Center in Tanzania and operates in accordance with Tanzania's National AIDS Control Programme's guidance. Testing for both children and infants (the latter of which requires a more sophisticated assay) is available.The day the clinic opened we celebrated this collaborative effort that would provide HIV-infected children in Dar es Salaam access to antiretroviral treatment. One of our first patients was a six-year-old boy whose mother, like Fatuma, was a participant in our TB vaccine trial. She had been advised to bring her son to us for HIV screening. Her son looked healthy so she was surprised and understandably distraught when his test results indicated that not only was he HIV-infected, but his CD4 percentage was very low. His mother was reluctant to have him started on antiretrovirals given his general appearance and young age—and that he was... (shrink)

We argue that Madole & Harden's distinction between shallow versus deep genetic causes can bring some clarity to causal claims arising from genome-wide association studies (GWASs). However, the authors argue that GWAS only finds shallow genetic causes, making GWAS commensurate with the environmental studies they hope to supplant. We also assess whether their distinction applies best to explanations or causes.

Maurice Blondel, best known for his 1893 work on Action, offers a window on the world of philosophers who negotiated the scientific disciplines at the turn of the twentieth century. During this amazing era of discoveries, Blondel encouraged the bold, encyclopedic spirit of science as well as the new standards coming into use for accumulating and judging observational evidence. However, he warned of reductionism, determinism, and phenomenism, trends which could be avoided or corrected if the nature and scope of science (...) were broadened. Such a broadening would introduce a more integrated and holistic understanding of the scientific quest. (shrink)

Are mechanisms for social attention influenced by culture? Evidence that social attention is triggered automatically by bottom-up gaze cues and is uninfluenced by top-down verbal instructions may suggest it operates in the same way everywhere. Yet considerations from evolutionary and cultural psychology suggest that specific aspects of one's cultural background may have consequence for the way mechanisms for social attention develop and operate. In more interdependent cultures, the scope of social attention may be broader, focusing on more individuals and relations (...) between those individuals. We administered a multi-gaze cueing task requiring participants to fixate a foreground face flanked by background faces and measured shifts in attention using eye tracking. For European Americans, gaze cueing did not depend on the direction of background gaze cues, suggesting foreground gaze alone drives automatic attention shifting; for East Asians, cueing patterns differed depending on whether the foreground cue matched or mismatched background cues, suggesting foreground and background gaze information were integrated. These results demonstrate that cultural background influences the social attention system by shifting it into a narrow or broad mode of operation and, importantly, provides evidence challenging the assumption that mechanisms underlying automatic social attention are necessarily rigid and impenetrable to culture. (shrink)

In contrast to the widely held view that emotions are obstacles to ideal epistemic functioning, emotions, as evaluative perceptual states, can contribute in significant ways to our achievement of valuable epistemic goods including justified beliefs, understanding, and wisdom. That emotions are evaluative perceptual states – call this the perceptual thesis of emotion – is evidenced by the extent of the structural and functional parallels between emotions and sense perceptions. Emotions, like sense perceptions, can be both original and acquired and are (...) distinct from the sensory inputs that give rise to them; they also resemble sense perceptions in being passive, intentional mental states with propositional content and they are sources of belief, while yet not themselves beliefs. Emotion also functions in parallel ways to sense perception with respect to the achievement of epistemic justification. Emotions, like their sense perceptual analogues, can and do function as justifying reasons or evidence for beliefs – call this the justificatory thesis of emotion. The justificatory thesis of emotion best explains plausible cases of justified beliefs formed on the basis of emotional experience, as well as the fact that we enjoy justification for evaluative beliefs bearing conceptual content indicative of emotional experience. Moreover, the justificatory thesis is not undermined by any of the strongest objections raised against it; namely, that emotions seem too unreliable to justify beliefs, that emotions themselves can be justified, and that we rarely cite emotions as our reasons for believing as we do. In another significant epistemic parallel between emotion and sense perception, emotional experience is necessary for the best and deepest human understanding of value just as sense perceptual experience is necessary for the best and deepest human understanding of the physical world. Emotion as evaluative perception is also essential to our achievement and actualization of wisdom. Wisdom is deep, appreciative ontological understanding of that which is good and it essentially involves virtuous concerns and emotion-dispositions. Indeed, not only is our initial pursuit of wisdom often prompted by an emotional experience, wisdom is also partially constituted by and initially exemplified in virtuous emotional perceptions of value. (shrink)

In Fear and Trembling, Søren Kierkegaard’s pseudonymous character, Johannes de Silentio, highlights the spiritual danger inherent in the Christian life of enjoying finite goods without giving into the temptation to idolize or become too dependent for our happiness on them. In light of this danger, de Silentio suggests that the life of faith depends on a special kind of courage—“the courage of faith.” Here, I offer an analysis of the courage of faith, underscoring its importance for the Christian life, and (...) I explore the interdependence of courage, faith, and a third virtue—humility. (shrink)

Between 1934 and 1937 Maurice Blondel, the French Roman Catholic philosopher best known for his 1893 work, Action, published a trilogy of writings. Out of these writings came a theological ontology of tremendous force, creativity, and coherence. The purpose of the present dissertation is to reassess the viability of Blondel's ontology for contemporary theology. The retrieval begins with John Milbank's 1990 investigation of Blondel's early philosophy. While Milbank focuses on the strengths of Blondel, he also highlights some critical weaknesses. The (...) dissertation argues that Blondel later came to recognize and correct these weaknesses in his trilogy. ;La pensee, the first volume of the trilogy, discusses the nature and development of thought. Recognizing the ontological structure of thought leads Blondel to present his doctrine of the transnatural elan for assimilation to God. The transnatural desire for God is compared with Henri de Lubac's notion of naturae desiderium and then applied to the modern problem of the relationship between nature and supernature. ;The second installment of the trilogy, L'etre et les etres , explores the mysterious relation of Being and beings. Blondel situates the discussion within the language of creation, identifying Being as Creator and beings as creatures. The analogy of creation allows him to forge the proper relationship between Being and beings. After Blondel's death, two different schools of thought emerged on the mystery of being: Karl Rahner's Thomism and Jean-Luc Marion's new phenomenology. Each school is reviewed and critiqued from a Blondelian perspective. ;The trilogy concludes with a long-awaited revision of L'action . It begins by distinguishing the idea of action from action itself and establishing the ontological difference of action. Action is presented ontologically as enacted power, which is investigated in its individual, social, and metaphysical forms. Individual action is identified as making, practicing, and contemplating. Social action is studied next, with the conclusion that the social being of enacted power is determined by either a philosophy of peace or violence. Finally, divine action is evaluated with regards to the language of causality and absolute power. Blondel proposes instead to describe God's activity in terms of pure action. (shrink)

Duncan Pritchard (2008, 2009, 2010, forthcoming) has argued for an elegant solution to what have been called the value problems for knowledge at the forefront of recent literature on epistemic value. As Pritchard sees it, these problems dissolve once it is recognized that that it is understanding-why, not knowledge, that bears the distinctive epistemic value often (mistakenly) attributed to knowledge. A key element of Pritchard’s revisionist argument is the claim that understanding-why always involves what he calls strong cognitive achievement—viz., cognitive (...) achievement that consists always in either (i) the overcoming of a significant obstacle or (ii) the exercise of a significant level of cognitive ability. After outlining Pritchard’s argument, we show (contra Pritchard) that understanding-why does not essentially involve strong cognitive achievement. Interestingly, in the cases in which understanding-why is distinctively valuable, it is (we argue) only because there is sufficiently rich objectual understanding in the background. If that’s right, then a plausible revisionist solution to the value problems must be sensitive to different kinds of understanding and what makes them valuable, respectively. (shrink)

Elite athletes, coaches and high-performance staff are exposed to a range of stressors that have been shown to increase their susceptibility to experiencing mental ill-health. Despite this, athletes may be less inclined than the general population to seek support for their mental health due to stigma, perceptions of limited psychological safety within sport to disclose mental health difficulties and/or fears of help-seeking signifying weakness in the context of high performance sport. Guidance on the best ways to promote mental health within (...) sporting environments is increasing, though current frameworks and position statements require greater focus on a whole of system approach, in which the needs of athlete, coaches and high-performance staff are considered within the context of the broader ecological system in which they operate and perform. This paper synthesizes existing research, reviewed for translatability by mental health professionals working in elite sport, to provide an evidence-informed framework with real world utility to promote mentally healthy environments for all stakeholders in elite sporting organizations, from athletes through to administrators. Recommendations are provided to positively impact the mental wellbeing of athletes and support staff, which may in turn influence athletic performance. This framework is intended to provide sporting organizations with evidence-informed or best practice principles on which they can develop or progress their policies to support mental health promotion and prevent the onset of mental health difficulties. It is intended that the framework can be adapted or tailored by elite sporting organizations based upon their unique cultural, contextual and resourcing circumstances. (shrink)

Should we regard Jennifer Lackey’s ‘Creationist Teacher’ as understanding evolution, even though she does not, given her religious convictions, believe its central claims? We think this question raises a range of important and unexplored questions about the relationship between understanding, factivity and belief. Our aim will be to diagnose this case in a principled way, and in doing so, to make some progress toward appreciating what objectual understanding—i.e., understanding a subject matter or body of information—demands of us. Here is the (...) plan. After some ground clearing in §1, §2 outlines and motivates a plausible working model—moderate factivity—for characterising the sense in which objectual understanding should be regarded as factive. §3 shows how the datum that we can understand false theories can, despite initial suggestions to the contrary, be assimilated straightforwardly within the moderate factivity model. §4 highlights how the inverse kind of case to that explored in §3—viz., a variant of Lackey’s creationist teacher case—poses special problems for moderate factivity. With reference to recent work on moral understanding by Hills, §5 proposes a solution to the problem, and §6 attempts to diagnose why it is that we might originally have been led to draw the wrong conclusion. (shrink)

This anthology collects the texts that defined the concept of biopolitics, which has become so significant throughout the humanities and social sciences today. The far-reaching influence of the biopolitical—the relation of politics to life, or the state to the body—is not surprising given its centrality to matters such as healthcare, abortion, immigration, and the global distribution of essential medicines and medical technologies. Michel Foucault gave new and unprecedented meaning to the term "biopolitics" in his 1976 essay "Right of Death and (...) Power over Life." In this anthology, that touchstone piece is followed by essays in which biopolitics is implicitly anticipated as a problem by Hannah Arendt and later altered, critiqued, deconstructed, and refined by major political and social theorists who explicitly engaged with Foucault's ideas. By focusing on the concept of biopolitics, rather than applying it to specific events and phenomena, this Reader provides an enduring framework for assessing the central problematics of modern political thought. _Contributors_. Giorgio Agamben, Hannah Arendt, Alain Badiou, Timothy Campbell, Gilles Deleuze, Roberto Esposito, Michel Foucault, Donna Haraway, Michael Hardt, Achille Mbembe, Warren Montag, Antonio Negri, Jacques Rancière, Adam Sitze, Peter Sloterdijk, Paolo Virno, Slavoj Žižek. (shrink)

This study explored the furry identity. Furries are humans interested in anthropomorphic art and cartoons. Some furries have zoomorphic tendencies. Furries often identify with, and/or assume, characteristics of a special/totem species of nonhuman animal. This research surveyed both furries and non-furry individuals attending a furry convention and a comparison group of college students . Furries commonly indicated dragons and various canine and feline species as their alternate-species identity; none reported a nonhuman-primate identity. Dichotomous responses to two key furry-identity questions produced (...) a two-by-two furry typology. These two independent dimensions are self-perception and species identity . One-quarter of the furry sample answered “yes” to both questions, placing them in the “Distorted Unattained” quadrant. This type of furry has certain characteristics paralleling gender-identity disorder. To explore this parallel, the furry typology, and the proposed construct of “Species Identity Disorder” needs further research. (shrink)

Emotions are pivotal in the manifestation and functioning of character traits. Traits such as virtues and vices involve emotions in diverse but connected ways. Some virtues are exemplified, in important part, by feeling emotions. Others are exemplified in managing, bypassing, or even eliminating emotions. And one virtue at least is exemplified in not-feeling a certain range of emotions. Emotions are a kind of perceptual state, namely construal, involving concern or caring about something, in which the elements of a situation are (...) organized and understood in terms of their significance or import. Emotional understanding can be morally right or wrong. As such construals, emotions can be morally excellent or perverse. Emotions thus have a logic or grammar that is crucial to their entering into, or being set upon by, or simply not occurring because of, virtues. The virtuous person is attuned, implicitly or reflectively, to this grammar, and that attunement constitutes one of the major dimensions of practical wisdom. An associationist psychology attempts to reduce the conceptual and intentional richness of emotions to mere associations or correlations of pleasant or unpleasant “affect” with various things. Such a psychology is fundamentally unfit to represent practical wisdom, and thus the moral life. We sketch an account of the generation and degeneration of character traits using the above conceptual framework and contrasting it with an associationist framework. (shrink)

_ Source: _Page Count 23 Emotions are pivotal in the manifestation and functioning of character traits. Traits such as virtues and vices involve emotions in diverse but connected ways. Some virtues are exemplified, in important part, by feeling emotions. Others are exemplified in managing, bypassing, or even eliminating emotions. And one virtue at least is exemplified in _not_-feeling a certain range of emotions. Emotions are a kind of perceptual state, namely _construal_, involving concern or caring about something, in which the (...) elements of a situation are organized and understood in terms of their significance or import. Emotional understanding can be morally right or wrong. As such construals, emotions can be morally excellent or perverse. Emotions thus have a logic or grammar that is crucial to their entering into, or being set upon by, or simply not occurring because of, virtues. The virtuous person is attuned, implicitly or reflectively, to this grammar, and that attunement constitutes one of the major dimensions of practical wisdom. An associationist psychology attempts to reduce the conceptual and intentional richness of emotions to mere associations or correlations of pleasant or unpleasant “affect” with various things. Such a psychology is fundamentally unfit to represent practical wisdom, and thus the moral life. We sketch an account of the generation and degeneration of character traits using the above conceptual framework and contrasting it with an associationist framework. (shrink)

This study explored the furry identity. Furries are humans interested in anthropomorphic art and cartoons. Some furries have zoomorphic tendencies. Furries often identify with, and/or assume, characteristics of a special/totem species of nonhuman animal. This research surveyed both furries and non-furry individuals attending a furry convention and a comparison group of college students. Furries commonly indicated dragons and various canine and feline species as their alternate-species identity; none reported a nonhuman-primate identity. Dichotomous responses to two key furry-identity questions produced a (...) two-by-two furry typology. These two independent dimensions are self-perception and species identity. One-quarter of the furry sample answered “yes” to both questions, placing them in the “Distorted Unattained” quadrant. This type of furry has certain characteristics paralleling gender-identity disorder. To explore this parallel, the furry typology, and the proposed construct of “Species Identity Disorder” needs further research. (shrink)

The most important and common solution to the Pyrrhonian skeptic’s regress problem is foundationalism. Reason-giving must stop somewhere, argues the foundationalist, and the fact that it does stop does not threaten knowledge or justification. The foundationalist has a problem, though; while foundationalism might adequately answer skepticism, it does not allow for a satisfying reply to the skeptic. The feature that makes a belief foundationally justified is not the sort of thing that can be given to another as a reason. Thus, (...) if foundationalism is true, we can only fall silent in the face of a challenge to our epistemically basic beliefs. Call this the practical or existential problem of foundationalism. Thomas Reid offers a rather stunning solution to this problem. Humor, he thinks, can be used to defend basic beliefs which cannot be defended by argument. We develop and defend an account on which Reid is correct and emotions such as rueful amusement can be invoked to rationally persuade the skeptic to accept foundationally justified beliefs. Then, inspired by Kierkegaard, we extend the account to foundational moral and religious beliefs. (shrink)

Current models of speech motor control rely on either trajectory-based control (DIVA, GEPPETO, ACT) or a dynamical systems approach based on feedback control (Task Dynamics, FACTS). While both approaches have provided insights into the speech motor system, it is difficult to connect these findings across models given the distinct theoretical and computational bases of the two approaches. We propose a new extension of the most widely used dynamical systems approach, Task Dynamics, that incorporates many of the strengths of trajectory-based approaches, (...) providing a way to bridge the theoretical divide between what have been two separate approaches to understanding speech motor control. The Task Dynamics (TD) model posits that speech gestures are governed by point attractor dynamics consistent with a critically damped harmonic oscillator. Kinematic trajectories associated with such gestures should therefore be consistent with a second-order dynamical system, possibly modified by blending with temporally overlapping gestures or altering oscillator parameters. This account of observed kinematics is powerful and theoretically appealing, but may be insufficient to account for deviations from predicted kinematics – i.e., changes produced in response to some external perturbations to the jaw, changes in control during acquisition and development, or effects of word/syllable frequency. Optimization, such as would be needed to minimize articulatory effort, is also incompatible with the current TD model, though the idea that the speech production systems economizes effort has a long history and, importantly, also plays a critical role in current theories of domain-general human motor control. To address these issues, we use Dynamic Movement Primitives (DMPs) to expand a dynamical systems framework for speech motor control to allow modification of kinematic trajectories by incorporating a simple, learnable forcing term into existing point attractor dynamics. We show that integration of DMPs with task- based point-attractor dynamics enhances the potential explanatory power of TD in a number of critical ways, including the ability to account for external forces in planning and optimizing both kinematic and dynamic movement costs. At the same time, this approach preserves the successes of Task Dynamics in handling multi-gesture planning and coordination. (shrink)

ABSTRACT Global biodiversity declines are increasingly recognized as profound ecological and social crises. In areas subject to colonialization, these declines have advanced in lockstep with settler colonialism and imposition of centralized resource management by settler states. Many have suggested that resurgent Indigenous-led governance systems could help arrest these trends while advancing effective and socially just approaches to environmental interactions that benefit people and places alike. However, how dominant management and conservation approaches might be decolonized (i.e., how their underlying colonial structure (...) might be addressed, transformed, and replaced) is not always clear. Here, we describe a ‘Decolonial Model of Environmental Management and Conservation’ as an alternative paradigm to dominant approaches of conservation and management. The tenets of the model describe characteristics that might be expected of decolonized management, contrasted with those of dominant state-led approaches such as those embedded in the North American Model of Wildlife Conservation. The model does not prescribe how Indigenous governments or communities ought to govern their own territories, but instead offers insights into how external management and conservation agencies and practitioners might support (or stop impeding) Indigenous-led governance. We illustrate the model with a conservation ‘bright spot’: grizzly bear stewardship in the area now referred to as the Great Bear Rainforest in British Columbia, Canada, with a focus on work led by or in collaboration with, and within the territories of, the Haíɫzaqv, Kitasoo/xai’xais, Nuxalk, and Wuikinuxv First Nations. While acknowledging the important context-specific variability among place-based management and conservation applications, we also discuss the model’s broader applicability. (shrink)

Risk communicators often need to communicate probabilistic predictions. On occasion, an event with 10% likelihood will occur, or one with 90% likelihood will not – a probabilistically unexpected ou...

Should we regard Jennifer Lackey’s ‘Creationist Teacher’ as understanding evolution, even though she does not, given her religious convictions, believe its central claims? We think this question raises a range of important and unexplored questions about the relationship between understanding, factivity and belief. Our aim will be to diagnose this case in a principled way, and in doing so, to make some progress toward appreciating what objectual understanding—i.e., understanding a subject matter or body of information—demands of us. Here is the (...) plan. After some ground clearing in §1, §2 outlines and motivates a plausible working model—moderate factivity—for characterising the sense in which objectual understanding should be regarded as factive. §3 shows how the datum that we can understand false theories can, despite initial suggestions to the contrary, be assimilated straightforwardly within the moderate factivity model. §4 highlights how the inverse kind of case to that explored in §3—viz., a variant of Lackey’s creationist teacher case—poses special problems for moderate factivity. With reference to recent work on moral understanding by Hills, §5 proposes a solution to the problem, and §6 attempts to diagnose why it is that we might originally have been led to draw the wrong conclusion. (shrink)

Neven Sesardic has recently defended his arguments in favour of racial naturalism—the view that race is a valid biological category—in response to my criticism of his work. While Sesardic claims that a strong version of racial naturalism can survive critique, he has in fact weakened his position considerably. He concedes that conventional racial taxonomy is arbitrary and he no longer identifies ‘races’ as human subspecies. Sesardic now relies almost entirely on Theodosius Dobzhansky’s notion of race-as-population. This weak approach to ‘race’—according (...) to which all genetic difference between populations is ‘racial’ and ‘the races’ are simply the populations we choose to call races—survived its early critiques. As it is being mobilised to support racial naturalism once more, we need to continue the debate about whether we should weaken the concept of race to mean ‘population’, or abandon it as a failed biological category. I argue that Sesardic’s case for racial naturalism is only supported by his continued mischaracterisation of anti-realism about biological race and his appeal to Dobzhansky’s authority. Rather than deflating the meaning of ‘race’, it should be eliminated from our biological ontology. (shrink)

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. The Supreme Court, Bronx County, declined to grant habeas corpus relief and order Happy’s transfer to an elephant sanctuary, relying, in part, on previous decisions that denied habeas relief for the NhRP’s chimpanzee clients, Kiko and Tommy. Those decisions use incompatible conceptions of ‘person’ which, when properly understood, are either philosophically inadequate or, in fact, compatible with Happy’s personhood.

Face perception is a highly conserved process that directs our attention from infancy and is supported by specialized neural circuitry. Oxytocin can increase accuracy and detection of emotional faces, but these effects are mediated by valence, individual differences, and context. We investigated the temporal dynamics of oxytocin’s influence on the neural substrates of face perception using event related potentials (ERP). In a double blind, placebo controlled within-subject design, 21 healthy male adults inhaled oxytocin or placebo and underwent ERP imaging during (...) two face processing tasks. Experiment 1 investigated effects of oxytocin on neural correlates of fearful versus neutral facial expressions, and Experiment 2 manipulated point-of-gaze to neutral faces. In Experiment 1, we found that oxytocin reduced N170 latency to fearful faces. In Experiment 2, N170 latency was decreased when participant gaze was directed to the eyes of neutral faces; however, there were no oxytocin-associated effects in response to different facial features. Findings suggest oxytocin modulates early stages of social perception for socially complex information such as emotional faces relative to neutral. These results are consistent with models suggesting oxytocin impacts the salience of socially informative cues during processing, which leads to downstream effects in behavior. Future work should examine how oxytocin affects neural processes underlying basic components of social behavior (such as, face perception) while varying emotional expression of stimuli or comparing different characteristics of participants (e.g., gender, personality traits). (shrink)

This study investigated the relationship between concussions and medication adherence among 247 adults experiencing homelessness in Oklahoma City, Oklahoma, who were prescribed medication for a psychiatric disorder. Participants were asked whether they had “ever experienced a blow to the head that caused a concussion,” and medication adherence was measured by asking participants whether they had taken their psychiatric medication yesterday. The data were analyzed using univariate and multivariable logistic regressions. Results showed that more than half of the sample had a (...) concussion history, and homeless adults with a concussion history had higher odds of non-adherence to psychiatric medications compared with those who reported no concussion history [OR = 2.13 ]. Findings suggest that medication non-adherence is associated with incurred concussions. Raising awareness among service providers of the relationship between traumatic brain injury and medication adherence may increase efforts to improve adherence in this underserved population. (shrink)

This research assessed how the performance and team skills of three-person teams working with an Intelligent Team Tutoring System on a virtual military surveillance task were affected by feedback privacy, participant role, task experience, prior team experience, and teammate familiarity. Previous work in Intelligent Tutoring Systems has focused on outcomes for task skill training for individual learners. As research extends into intelligent tutoring for teams, both task skills and team skills are necessary for good team performance. This work includes a (...) brief review of previous research on ITTSs, feedback, teams, and teamwork, including the recounting of two categories of a framework of teamwork performance, Communication and Cognition, which are relevant to the present study. This research examines the effects of an intelligent agent, as well as features of the team, its members, and the task being undertaken, on team communication and team situation awareness. Thirty-seven teams of three participants, each at their own computer running a multiplayer surveillance simulation, were given just-in-time private or public performance feedback during four 5-min trials. In the fourth trial, two of the three participants switched roles. Feedback type, teamwork experience, and teammate familiarity had no statistically significant effect on communication or team situation awareness. However, higher levels of role experience and task experience showed significant and medium-sized effects on communication performance. Results, based on performance data and structured interview responses, also revealed areas of improvement in future feedback design and a potential benchmark for feedback frequency in an action-oriented serious game-based ITTS. Among the conclusions are six design objectives for future ITTSs, establishing a foundation for future research on designing effective ITTSs that train interpersonal skills to nascent teams. (shrink)

The UNESCO Statements on Race of the early 1950s are understood to have marked a consensus amongst natural scientists and social scientists that ‘race’ is a social construct. Human biological diversity was shown to be predominantly clinal, or gradual, not discreet, and clustered, as racial naturalism implied. From the seventies social constructionists added that the vast majority of human genetic diversity resides within any given racialised group. While social constructionism about race became the majority consensus view on the topic, social (...) constructionism has always had its critics. Sesardic (2010) has compiled these criticisms into one of the strongest defences of racial naturalism in recent times. In this paper I argue that Sesardic equivocates between two versions of racial naturalism: a weak version and a strong version. As I shall argue, the strong version is not supported by the relevant science. The weak version, on the other hand, does not contrast properly with what social constructionists think about ‘race’. By leaning on this weak view Sesardic’s racial naturalism intermittently gains an appearance of plausibility, but this view is too weak to revive racial naturalism. As Sesardic demonstrates, there are new arguments for racial naturalism post-Human Genome Diversity Project. The positive message behind my critique is how to be a social constructionist about race in the post-genomic era. (shrink)

C.H. Waddington is today remembered chiefly as a Drosophila developmental geneticist who developed the concepts of “canalization” and “the epigenetic landscape.” In his lifetime, however, he was widely perceived primarily as a critic of Neo-Darwinian evolutionary theory. His criticisms of Neo-Darwinian evolutionary theory were focused on what he saw as unrealistic, “atomistic” models of both gene selection and trait evolution. In particular, he felt that the Neo-Darwinians badly neglected the phenomenon of extensive gene interactions and that the “randomness” of mutational (...) effects, posited in the theory, was a false postulate. This last criticism dealt with the phenomenon known today as “developmental constraints.” Although population genetics itself has evolved considerably from its form at mid-20th century, much of Waddington’s critique, it is argued here, retains cogency. Yet, he did not attempt to develop a full-fledged alternative theory himself. Perhaps most surprisingly, in retrospect, is that he did not try to marry his work on gene interactions in development with his evolutionary interests, to create a theory of “genetic networks” and their evolution. Whether evolutionary genetics today will incorporate “network thinking” as a central element or whether there will be a general retreat to the more atomistic approach offered by genomics, remains an open question. (shrink)

In the broadest sense of the term, fallibilism is an anti-dogmatic intellectual stance or attitude: an openness to the possibility that one has made an error and an accompanying willingness to give a fair hearing to arguments that one’s belief is incorrect (no matter what that belief happens to be about). So understood, fallibilism’s central insight is that it is possible to remain open to new evidence and arguments while also reasonably treating an issue as settled for the purposes of (...) current inquiry and action. Fallibilism, so construed, was given its most influential formulation – and its name – by C. S. Peirce, though it was advocated by earlier philosophers as well, particularly the later ancient skeptic Philo of Larissa and perhaps also Hume. Contemporary epistemologists almost universally agree in endorsing this intellectual stance; it is part of the undisputed framework within which contemporary epistemological theorizing takes place. (shrink)

The starting point of the article is claim, that the well-known distinction between natural sciences as explaining and human sciences as interpreting made by W. Dilthey and distinction between idiographic and nomothetic sciences made by H. Rickert are both inadequate at present. Human sciences separate their research areas using logics and statistics and formulating many generalizations and even laws. So it can be argued that they can give explanations sensu stricto. First part of the article describes contemporary controversy naturalism-anti­naturalism in (...) formulation of M. Salmon, who presents the third middle way, that some human science as linguistics or evolutionary psychology can give causal explanations without appealing to human reasons as causes. This standpoint, however, can lead to reductionism and necessity of separating in each human science some kind of "scientific core", which seems to be undesirable. Second part of the article presents possible applications of the D-N model of explanation of C. G. Hempel in human sciences, which is connected with well-known controversy whether these sciences formulate any laws (especially history but also linguistics for example). Leaving out, however, this important question and accepting statement proposed by J. Such, that some generalizations can serve as a premises in D-N arguments, we can claim that some D-N explanations are possible also in human sciences. (shrink)

Most of the literature on pharmacogenetics assumes that the main problems in implementing the technology will be institutional ones (due to funding or regulation) and that although it involves genetic testing, the ethical issues involved in pharmacogenetics are different from, even less than, ‘traditional’ genetic testing. Very little attention has been paid to how clinicians will accept this technology, their attitudes towards it and how it will affect clinical practice. -/- This paper presents results from interviews with clinicians who are (...) beginning to use pharmacogenetics and explores how they view the ethics of pharmacogenetic testing, its use to exclude some patients from treatment, and how this kind of testing fits into broader debates around genetics. In particular this paper examines the attitudes of breast cancer and Alzheimer’s disease specialists. The results of these interviews will be compared with the picture of pharmacogenetics painted in the published literature, as a way of rooting this somewhat speculative writing in clinical practice. -/- . (shrink)

The aim of the paper is to show that W. V. O. Quine's animadversions against modal logic did not get the same attention that is considered to be the case nowadays. The community of logicians focused solely on the technical aspects of C. I. Lewis’ systems and did not take Quine's arguments and remarks seriously—or at least seriously enough to respond. In order to assess Quine's place in the history, however, his relation to Carnap is considered since their notorious break (...) was about the status of extensionality and modal logic. Since much of the works about the history of analytic philosophy is centered on the relationship of Quine and Carnap, their break about modality deserves much more attention—it also sheds some light on why should anyone wonder about Quine's early arguments against modal logic. The paper ends with some further considerations regarding the early formation of modal logic and hitherto unconsidered problematic issues. (shrink)

In the mid-1990s, the company Human Genome Sciences submitted three potentially revolutionary patent applications to the US Patent and Trademark Office, each of which claimed the entire genome sequence of a microorganism. The patent examiners, however, objected to these applications, and after negotiation they were eventually re-written to resemble more traditional gene patents. In this paper, which is based on a study of the patent examination files, we examine the reasons why these patent applications were unsuccessful in their original form. (...) We show that with respect to utility and novelty, the patent attorney’s case built on an understanding of the genome as a computer-related invention. The patent examiners did not object to the patenting of complete genome sequences as computer-related inventions on moral grounds or in terms of the distinction between a discovery and an invention. Instead, their objections were based on classification, rules and procedure. Rather than patent examiners having a notion of a genome that should not be patented, the notion of a ‘genome’, and the ways in which it may be different from a ‘gene’, played no role in these debates. We discuss the consequences of our findings for patenting in the biosciences. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Plot Taxonomies and IntentionalityJon AdamsEver popular among the various topics occupying non-academic conversations about literature—such as the identity of the real author of the plays attributed to "Shakespeare"—is the notion that there exists only a finite number of storylines, and that all the stories we know are only ever complications or rehearsals of these few, elementary plots. What is the status of that claim? The issue gains a renewed (...) relevance in light of literary criticism's recent interest in the possibilities of employing evolutionary psychology as a means of naturalising literary study, but interest in plot taxonomies stretches a long way back. Why might we seek to categorise plots into a finite taxonomy? And what are the implications of the claim if true?Organising literature into any classificatory scheme is an attempt to achieve something like the coherence that the natural sciences have achieved—in chemistry and physics with the composition of the periodic table, and in biology with Linnaean classification. Much of science's epistemic prestige is rooted in the enormous success with which they have organised and categorised their subject of study. In searching for mechanism and pattern, the natural sciences proceed confidently from the belief that those mechanisms and patterns exist to be discovered, and that (relatively) simple rules underlie the manifest complexity of natural phenomena.Unfortunately, the study of literary fiction has no such security. There are two senses here in which we can talk of literature being patterned. At the micro-level, we have the question of whether individual works can be thought of as internally patterned. Usually, this type of patterning is easy enough to establish and recognise, and something the author is (or ought to be) in a good position to control. But, of course, internal [End Page 102] structures are not always conspicuous, and readers faced with an overtly complex text, like Pound's Cantos, or Finnegans Wake, have no guarantee that there is sense to be made of it. Surface complexity may shield a profound and subtle architecture, or the work may be as unstructured, fragmentary, and chaotic as it initially appears. A frustrated Wayne C. Booth draws attention to the problem: "One can't be sure that Finnegans Wake is not a great novel; perhaps someday readers will discover that the complex structure they now dream of and quarrel about is a realizable structure, an experienced structure. I doubt it, but it may happen. Until then, each new intricacy discovered... reveals precisely nothing more than that: a new intricacy."1 What's missing is a conceptual centre around which overall coherence might be achieved from what had seemed to be unconnected parts. Even so, if this sort of centre cannot be found in the individual work, it may yet obtain between works. In other words, The Cantos or Finnegans Wake may yet occupy nodal roles in a larger system, within which they acquire a previously unrecognized unity and order. This type of organization is something the individual author is obviously in a much less suitable position to control. Nonetheless, mapping out this larger, macro-level order is a task that literary criticism might want to take on. There is the example Borges uses of how Kafka's work retrospectively confers a familial similarity upon previously unconnected works. The quality of being "Kafkaesque" is the only thing common to the pieces, but was not apparent (or rather—the paradox that excites Borges—did not exist) prior to Kafka's writing.2 This is the second sense in which literature might be thought of as patterned; that is, not within works, but across them. On the larger scale, is it possible that literature as a whole could be understood as patterned?The notion that literature can be understood "as a whole," and its corollary, that a literature so understood would submit to taxonomical classification, is an enduring one. Anthropologists and art historians have long acknowledged that there appear to be recurring themes, motifs, and commonalities across world cultures, and consequently, commonalities among the narratives those cultures construct and consume. Cataloguing these similarities has produced a variety of classificatory systems.In the mid-nineteenth century, German scholar Adolf... (shrink)

Without extensive argument or elaboration of implications, the author presents Smith's views on ethical matters peculiarly important to our own era. Having previously assumed that Smith's statement alone is sufficient, the author permits him to speak extensively.--C. E. B.

In lieu of an abstract, here is a brief excerpt of the content:How Old Are Modern Rights? On the Lockean Roots of Contemporary Human Rights DiscourseS. Adam SeagraveArguing for the proper placement of John Locke’s natural rights theory within intellectual history is a particularly high-stakes enterprise for historians of political thought and political theorists alike. This is due in large part to the fact that, as Brian Tierney notes in his recent study, it is “widely agreed that Locke’s work (...) was an important influence in the formation of modern liberal ideas, including ideas concerning rights.”1 Our understanding of Locke thus contributes to our reflective self-understanding as “modern liberals” (of one stripe or another) to an extent perhaps unequaled by any other thinker so far removed from our own time.As a result of the rare promise of studying Locke’s natural rights theory, there has been no shortage of scholarly attempts to determine its place in intellectual history on the basis of Locke’s own writings and their relation both to preceding and subsequent traditions and modes of thought. Although John Dunn had argued in his influential study that Locke’s political thought was too thoroughly steeped in theology to remain relevant in the contemporary context, this thesis has since been persuasively challenged (albeit in very different ways) by Simmons, Zuckert and Waldron, among others.2 Each of these scholars has contributed to an emerging agreement [End Page 305] that the thread of Locke’s natural rights theory may indeed be carried all the way up to current political and moral debates in some form or another. The precise length of this thread as it extends in the other historical direction has, however, remained a point of heated controversy. The scholarly literature on this issue may be broadly described in terms of a spectrum determined by two opposing emphases in understanding the relation of Locke’s natural rights theory to its medieval predecessors: a continuity emphasis and a discontinuity emphasis.On the discontinuity end of the spectrum stand those such as Michel Villey, Leo Strauss, C. B. Macpherson and, more recently, Michael Zuckert who argue for the existence of some sort of “Copernican moment” separating medieval natural rights theories from their modern counterparts.3 Whether this moment is identified with William of Ockham in the fourteenth century or Hobbes in the seventeenth century, these scholars tend to emphasize the distinctively “modern” character of Lockean natural rights theory and its significant departures from medieval modes of thought. According to many of the advocates of discontinuity, Lockean natural rights are not only “modern” in their political applications but also in their more profound meaning as foundations for morality, and particularly in their newly conceived relation to the concept of natural law.4The continuity end of the spectrum is, perhaps, more variegated, including scholars such as Tuck, Tierney, Tully, Oakley, Nederman, Coleman, and Swanson, among others.5 Despite their many important differences, [End Page 306] these scholars each focus upon the similarities between various elements or strains of medieval thought and modern natural rights theories rather than the differences between them. Insofar as the scholars on this end of the spectrum explicitly consider Locke’s natural rights theory, they tend to emphasize Locke’s intellectual debt to various preceding traditions and thinkers rather than his innovations upon them. Building explicitly upon the work of Tuck, Tierney and Tully, Janet Coleman finds “some extraordinarily Lockean moments” in the medieval thinkers John of Paris and Godefroid of Fontaines, and argues that Locke ought to be understood as contributing to this medieval tradition of thought rather than departing from it.6 Scott Swanson, in turn, builds upon Coleman’s scholarship in carefully connecting medieval understandings of the rights of subsistence and the principle of extreme necessity to Locke’s natural rights theory. Swanson initially goes even further than Coleman in asserting that “all of Locke’s celebrated doctrine is here [in John of Paris’s writings] offered in a nutshell” before concluding on the more moderate note, echoed by Cary Nederman, that Locke’s “application of natural rights of subsistence to politics” may indeed have been something “new under the sun.”7Brian Tierney, who has long been a prominent... (shrink)

Without extensive argument or elaboration of implications, the author presents Smith's views on ethical matters peculiarly important to our own era. Having previously assumed that Smith's statement alone is sufficient, the author permits him to speak extensively.--C. E. B.

According to the most recent articulation of her view, Marilyn Adams’s reply to the problem of horrendous evils states that God offers compensation to those who experience horrendous evils. This compensation includes the good of the incarnation of God and the good of identification with God in virtue of suffering horrendous evils. Andrew Gleeson has raised a series of objections to Adams’s recent articulation. I argue that all of Gleeson’s arguments fail or fail to pose a distinct challenge. I then (...) present a different challenge: that her view provides insufficient compensation for horrendous evils. I conclude by suggesting a development of her view. (shrink)

ICAP is a theory of active learning that differentiates students’ engagement based on their behaviors. ICAP postulates that Interactive engagement, demonstrated by co‐generative collaborative behaviors, is superior for learning to Constructive engagement, indicated by generative behaviors. Both kinds of engagement exceed the benefits of Active or Passive engagement, marked by manipulative and attentive behaviors, respectively. This paper discusses a 5‐year project that attempted to translate ICAP into a theory of instruction using five successive measures: (a) teachers’ understanding of ICAP after (...) completing an online module, (b) their success at designing lesson plans using different ICAP modes, (c) fidelity of teachers’ classroom implementation, (d) modes of students’ enacted behaviors, and (e) students’ learning outcomes. Although teachers had minimal success in designing Constructive and Interactive activities, students nevertheless learned significantly more in the context of Constructive than Active activities. We discuss reasons for teachers’ overall difficulty in designing and eliciting Interactive engagement. (shrink)

Most contemporary interpreters of Aquinas think that he rejects the possibility of intermittent or “gappy” existence. Thus they think that the soul’s natural survival after death is a necessary part of Aquinas’s defense of the possibility of the resurrection. Yet this contemporary consensus rests on shaky foundations. For on the basis of a widely neglected quodlibet question, earlier interpreters of Aquinas as eminent as John Capreolus and Francis Sylvester Ferrara recognized that Aquinas reserves to God the power to annihilate material (...) substances, including human beings, and then re-create them numerically the same. If these earlier interpreters are right, then the contemporary consensus is wrong. But Adam Wood argues that they are not right. He attempts to vindicate the contemporary consensus by offering an alternative reading of Aquinas’s quodlibet on annihilation and re-creation, providing textual evidence of Aquinas’s rejection of the possibility of “gappy” existence, criticizing the reading given to this evidence by Aquinas’s earlier interpreters, and mounting a philosophical case against the possibility of “gappy” existence based on his preferred interpretation of Aquinas’s theory of the principle of individuation. In this paper I come to the defense of Aquinas’s earlier interpreters. Wood’s alternative reading of Aquinas’s quodlibet is impossible to square with the text itself. Close inspection of Wood’s textual evidence shows that some of the readings of Aquinas’s earlier interpreters are much more plausible than Wood allows, making his textual case much weaker than he admits. And his philosophical case against the possibility of “gappy” existence begs the question. (shrink)